Platelet-rich fibrin (PRF) treatment is a regenerative therapy often used in foot and ankle conditions to promote healing and tissue repair. PRF is derived from the patient’s own blood and is rich in platelets, fibrin, and growth factors that stimulate the healing process. It provides a scaffold for cell migration and tissue regeneration. It is a minimally invasive procedure, done in the outpatient setting, which minimizes the risk of immune reactions, enhances long term healing and is cost effective as compared to other regenerative treatments and synthetic growth factor treatments. It is used to treat foot conditions such as tendinitis, arthritis, plantar fasciitis, post-surgical healing and diabetic foot ulcers.